Dipeptide-2

Dipeptide-2 consists of two natural amino acids linked by a peptide bond, with no additional chemical modifications. It is produced by standard solid-phase peptide synthesis and purified by high-performance liquid chromatography to >98 % purity. The simple dipeptide structure ensures good skin penetration when formulated in serums or creams. Identity and purity are confirmed by mass spectrometry.

Dipeptide-2 promotes lymphatic microcirculation (fluid drainage in tiny vessels) and strengthens capillary walls in the dermis (skin’s middle layer). Improved lymph flow helps clear excess interstitial fluid that causes puffiness, while enhanced capillary integrity reduces leakage that contributes to dark circles. These combined actions help normalize fluid balance under the eyes. In human tests, improvements appeared after consistent twice-daily application.

The peptide is studied primarily for its ability to reduce under-eye bags and dark circles. In cosmetic trials, subjects applying formulations with Dipeptide-2 reported visibly decreased puffiness and more uniform skin tone around the eyes. Effects typically became noticeable within four weeks of twice-daily use. The peptide is incorporated in a variety of eye-care products as a non-invasive alternative to injectables.

Reported adverse effects are minimal, with occasional mild irritation or redness at the application site. No systemic side effects or hormonal impacts have been documented in human use. Safety in pregnancy or on compromised skin has not been specifically studied. A patch test is recommended for sensitive individuals before full-face application.

Dipeptide-2 is synthesized by Fmoc solid-phase peptide synthesis on a resin support, coupling two amino acids in sequence. After cleavage from the resin, it is purified by preparative HPLC to >98 % purity. Mass spectrometry verifies correct molecular weight and sequence. Manufacturing follows cosmetic-industry good manufacturing practices (GMP).

Dipeptide-2 is approved as a cosmetic ingredient worldwide and may be included in over-the-counter skincare products under regional cosmetic regulations. It is not regulated as a pharmaceutical and may not make medical claims. Products must list it under its INCI name (“Dipeptide-2”) on packaging.

Formulations typically contain 2–5 % Dipeptide-2 in serums or creams. Recommended application is twice daily to the under-eye area on clean, dry skin. No formal dosing guidelines exist beyond manufacturer instructions. Consistent use for at least four weeks is advised to assess visible results.

Do apply gently with your finger to avoid tugging delicate skin.Do follow with sunscreen during daytime use to protect skin tone.Don’t apply to broken or inflamed skin.Don’t expect effects comparable to cosmetic injectables.

Q: How soon will I see results?A: Most users notice reduced puffiness after about four weeks of twice-daily use.Q: Can it lighten dark circles permanently?A: It improves fluid drainage and capillary strength, but underlying pigmentation may require additional treatments.Q: Is it suitable for sensitive skin?A: Generally yes, but a patch test is recommended to check for irritation.