Pentapeptide-18
Pentapeptide-18 is a synthetic five–amino-acid peptide designed to ease superficial facial muscle tension, smoothing out fine expression lines. Applied in skincare serums or creams, it gently calms repetitive muscle movements under the skin, reducing wrinkle depth and improving overall skin smoothness over several weeks of use.
Compound Overview
About the product
The sequence is Arg–Pro–Leu–Gly–NH₂, with C-terminal amidation to enhance stability in formulations. It contains only natural L-amino acids and no non-natural modifications. Pentapeptide-18 is synthesized by Fmoc solid-phase peptide methods and purified by HPLC to ≥98 % purity. Mass spectrometry confirms its sequence and molecular weight.
Pentapeptide-18 binds to neuroreceptors in superficial dermal muscle fibers, reducing calcium release and thereby decreasing micro-muscle contractions that create expression lines. It does not block neurotransmitter release completely but dampens the intensity of repetitive movements. This localized action smooths skin texture over time without systemic effects.
The peptide is used primarily to improve the appearance of fine lines and wrinkles. In cosmetic studies, creams containing Pentapeptide-18 showed reduced wrinkle depth and enhanced skin smoothness after several weeks of daily use. Its non-invasive profile makes it a popular ingredient in anti-aging serums and creams as an alternative to injectables.
Reported adverse effects are minimal and include occasional mild redness or tingling at the application site. No systemic toxicity or hormonal effects have been documented. Safety in pregnancy, lactation, and on compromised skin has not been formally evaluated. A patch test is recommended for sensitive skin.
Pentapeptide-18 is produced via Fmoc solid-phase peptide synthesis, sequentially coupling five amino acids on a resin support. After cleavage, it is purified by preparative HPLC to cosmetic-grade purity. Quality control uses mass spectrometry and analytical HPLC to verify sequence integrity and purity.
Pentapeptide-18 is approved as a cosmetic ingredient under regulations in the U.S., EU, and many other regions. It may be included in over-the-counter skin-care products at manufacturer-specified concentrations. It is not regulated as a pharmaceutical and may not carry therapeutic claims. Products list it under its INCI name.
Topical formulations typically contain 2–5 % Pentapeptide-18. Recommended application is once or twice daily to clean, dry skin. No formal dosing guidelines exist beyond manufacturer instructions. Consistent use for at least four weeks is advised to assess visible effects.
Do apply gently to areas prone to expression lines (forehead, crow’s feet).Do perform a patch test before first use if you have sensitive skin.Don’t apply to broken or inflamed skin without medical advice.Don’t expect immediate results, allow several weeks for effects.
Q: How soon will I see results?A: Improvements in wrinkle appearance typically occur after four to six weeks of daily use.Q: Can it replace Botox?A: No; its effect is milder and develops more slowly than injectable neuromodulators.Q: Is it safe for all skin types?A: Generally yes, but a patch test is recommended for very sensitive skin.
For research use only. Not approved for medical use.
