Snap-8
Snap-8 is an eight–amino-acid peptide that targets the tiny muscles under facial skin to reduce repetitive contractions responsible for expression lines. It works by interrupting the molecular machinery (SNARE complex) that releases the neurotransmitter acetylcholine, leading to gentler muscle movements. Used in anti-aging serums and creams, Snap-8 gradually smooths fine wrinkles, especially around the eyes and forehead, without injections.
Compound Overview
About the product
The sequence is Ac-Arg-His-Lys-Asp-Gly-Pro-Val-NH₂, with N-terminal acetylation and C-terminal amidation to enhance stability. It contains only natural L-amino acids plus those terminal modifications. Snap-8 is synthesized by Fmoc solid-phase peptide methods and purified by HPLC to ≥95 % purity. Mass spectrometry confirms its correct sequence and modifications.
Snap-8 interferes with the SNARE complex that drives neurotransmitter release at neuromuscular junctions in the skin. By reducing the release of acetylcholine, it lessens micro-contractions of superficial facial muscles. This dampening of muscle activity smooths out fine expression lines over time. Its action is local and does not affect systemic muscle function.
The peptide is used primarily to soften fine lines and wrinkles in facial skincare. In cosmetic studies, products containing Snap-8 showed smoother skin texture and reduced wrinkle depth after several weeks of daily application. It offers a gentle, non-injectable alternative to neuromodulator treatments. Snap-8 is often combined with other anti-aging ingredients for enhanced effect.
Reported adverse reactions are minimal, most commonly mild skin redness or tingling at the application site. No systemic effects or hormonal changes have been documented. Safety in pregnancy, lactation, and on damaged skin has not been formally studied. A patch test is recommended for sensitive skin.
Snap-8 is produced by Fmoc solid-phase peptide synthesis on a resin support, sequentially coupling eight amino acids. After cleavage, it is purified by preparative HPLC to cosmetic-grade purity. Quality control uses mass spectrometry and analytical HPLC to verify sequence integrity and purity. Manufacturing follows cosmetic-industry good manufacturing practices.
Snap-8 is approved as a cosmetic ingredient in the U.S., EU, and many other regions. It may be included in over-the-counter skincare products under concentration limits set by local regulations. It is not regulated as a pharmaceutical and may not carry drug claims. Products list it under its INCI name (“Acetyl Octapeptide-3”).
Topical formulations typically contain 2–5 % Snap-8 in serums or creams. Recommended application is once or twice daily to clean, dry skin. No formal dosing guidelines exist beyond manufacturer instructions. Consistent use for at least four weeks is advised to assess visible effects.
Do apply gently to areas prone to expression lines (forehead, around eyes).Do perform a patch test before first use if you have sensitive skin.Don’t apply to broken or inflamed skin.Don’t expect immediate results, allow several weeks for effects.
Q: How soon will I see results?A: Most users notice smoother skin and reduced fine lines after four to six weeks.Q: Can Snap-8 replace Botox?A: No; its effect is milder and develops more slowly compared with injectables.Q: Is it suitable for all skin types?A: Generally yes, though a patch test is recommended for very sensitive skin.
For research use only. Not approved for medical use.
